Anti-CX43/GJA1 Polyclonal Antibody (HB620014)

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Datasheet

Overview

Catalog No.

HB620014

Description

Anti-CX43/GJA1 Polyclonal Antibody (HB620014) is a rabbit polyclonal antibody detecting GJA1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Dog.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat, Bos taurus, Dog, Chlorocebus aethiops, Erinaceus europaeus, Chicken, Macaca fascicularis, Oryctolagus cuniculus, Pig, Ursus americanus

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CX43/GJA1 (Phe232-Ile382).

Target

GJAL, Connexin-43, GJA1, Cx43, Gap junction 43 kDa heart protein, Gap junction alpha-1 protein

Purification

Purified by antigen affinity column.

Accession

P17302

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Gap junction alpha-1 protein (CX43/GJA1) is a ~43 kDa protein. Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph (Probable). Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in the conductive system of ventricular myocardium and heart morphogenesis.

1. Ablasser, A. et al. (2013) Nature 503, 530-4. PMID: 24077100

2. Pépin, G. et al. (2020) mBio 11. PMID: 31992625

3. Huai, W. et al. (2025) Immunity 58, 797-810.e6. PMID: 40010341

Note

For research use only.

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