Anti-SNCA Polyclonal Antibody (HW755014)

Name: Anti-SNCA Polyclonal Antibody
Brand: abinScience
SKU: HW755014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HW755014

Description

Anti-SNCA Polyclonal Antibody (HW755014) is a rabbit polyclonal antibody detecting SNCA in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Ateles geoffroyi, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat, Ateles geoffroyi, Bos taurus, Erythrocebus patas, Gorilla gorilla gorilla, Lagothrix lagotricha, Macaca fascicularis, Macaca mulatta, Pan paniscus, Pan troglodytes, Pongo abelii, Saguinus labiatus, Serinus canaria, Pig

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human SNCA (Met1-Ala140).

Target

Alpha-synuclein, PARK1, Non-A4 component of amyloid precursor, NACP, Non-A beta component of AD amyloid, SNCA

Purification

Purified by antigen affinity column.

Accession

P37840

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Alpha-synuclein (SNCA) is a ~14 kDa protein. Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging.

1. Burré, J. et al. (2010) Science (New York, N.Y.) 329, 1663-7. PMID: 20798282

2. Butler, B. et al. (2015) The Journal of biological chemistry 290, 29542-54. PMID: 26442590

3. Logan, T. et al. (2017) Nature neuroscience 20, 681-689. PMID: 28288128

4. Huang, CC. et al. (2018) Journal of cell science 131. PMID: 30404828

Note

For research use only.

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