Anti-Human ROR2/NTRKR2 Antibody (GK-5A1) (HX930107)

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Datasheet

Overview

Catalog No.	HX930107
Description	Anti-Human ROR2/NTRKR2 Antibody (GK-5A1) [GK-5A1] (HX930107) is a mouse monoclonal antibody detecting NTRKR2 in ELISA, FCM. Suitable for Human, Monkey, and Mouse. Highlights ●Flow Cytometry — Validated for flow cytometry applications. ●Multi-Species — Cross-reactive for translational research.
Species reactivity	Human, Monkey, Mouse
Applications	ELISA, FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	GK-5A1
Clonality	Monoclonal
Target	ROR2, Neurotrophic tyrosine kinase, receptor-related 2, NTRKR2, Tyrosine-protein kinase transmembrane receptor ROR2
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q01974
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Tyrosine-protein kinase transmembrane receptor ROR2 (NTRKR2) is a ~104 kDa protein. Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling. 1. Liu, Y. et al. (2007) Molecular endocrinology (Baltimore, Md.) 21, 3050-61. PMID: 17717073 2. Bainbridge, TW. et al. (2014) PloS one 9, e102695. PMID: 25029443
Note	For research use only.

Images

Bioactivity

Detects ROR2/NTRKR2 in indirect ELISAs.
Flow CytoMetry

Flow-cytometry using anti-human ROR2 antibody. Untransfected cells (blue Histogram) and Transfected cells (Yellow Histogram) were stained with an anti-human ROR2 monoclonal antibody (Catalog: HX930107) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Mouse IgG H&L Polyclonal Antibody, FITC (abinScience: MF690414) and cells analysed on a NovoCyte Flow Cytometer.