Mouse Anti-Human PMEL17/ME20M Recombinant Antibody (17A9) (HW380107)

Name: Mouse Anti-Human PMEL17/ME20M Recombinant Antibody (17A9)
Brand: abinScience
SKU: HW380107
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HW380107
Brand	abinScience
Species reactivity	Human, Mouse, Rat, Monkey
Applications	ELISA, FCM, IHC
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	17A9
Clonality	Monoclonal
Target	ME20M, Melanocyte protein PMEL, Silver locus protein homolog, Secreted melanoma-associated ME20 antigen, D12S53E, 95 kDa melanocyte-specific secreted glycoprotein, SILV, P100, Premelanosome protein, PMEL17, ME20S, PMEL, ME20-S, ME20-M, P26, P1, Melanocytes lineage-specific antigen GP100, Melanocyte protein Pmel 17, Melanoma-associated ME20 antigen
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P40967
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.09% Sodium azide. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Melanocyte protein PMEL (PMEL17/ME20M) is a ~70 kDa protein. Forms physiological amyloids that play a central role in melanosome morphogenesis and pigmentation. The maturation of unpigmented premelanosomes from stage I to II is marked by assembly of processed amyloidogenic fragments into parallel fibrillar sheets, which elongate the vesicle into a striated ellipsoidal shape. In pigmented stage III and IV melanosomes, the amyloid matrix serves as a platform where eumelanin precursors accumulate at high local concentrations for pigment formation. May prevent pigmentation-associated toxicity by sequestering toxic reaction intermediates of eumelanin biosynthesis pathway.
Note	For research use only.

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Western blot

Western blot analysis was performed using anti-PMEL monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human PMEL (Catalog No: HW380012)
Lane 2: negative control
Bioactivity

Detects recombinant human PMEL (Catalog No: HW380012) in indirect ELISA

References

Datasheet

Mouse Anti-Human PMEL17/ME20M Recombinant Antibody (17A9).pdf

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Mouse Anti-Human PMEL17/ME20M Recombinant Antibody (17A9) (HW380107)

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Datasheet

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