Anti-Human MERTK/MER Recombinant Antibody (Z10) (HC320107)

Name: Anti-Human MERTK/MER Recombinant Antibody (Z10)
Brand: abinScience
SKU: HC320107
Price: 191 USD
Availability: InStock

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Overview

Catalog No.	HC320107
Species reactivity	Human
Applications	ELISA, FCM
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	Z10
Clonality	Monoclonal
Target	Receptor tyrosine kinase MerTK, Proto-oncogene c-Mer, Tyrosine-protein kinase Mer, MERTK, MER
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q12866
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.09% Sodium azide. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Tyrosine-protein kinase Mer (MERTK) is a ~110 kDa protein. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. 1. Moon, B. et al. (2020) Cells 9. PMID: 32640697
Note	For research use only.

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Bioactivity

Detects Human MERTK/MER in indirect ELISAs.

References

Datasheet

Anti-Human MERTK/MER Recombinant Antibody (Z10).pdf

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Formula

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Recombinant Proteins

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Anti-Human MERTK/MER Recombinant Antibody (Z10) (HC320107)

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