

| Catalog No. | HS803147 |
|---|---|
| Species reactivity | Human |
| Applications | ELISA, FCM |
| Host species | Mouse |
| Isotype | IgG2a |
| Clone ID | SAA0776 |
| Conjugation | PerCP |
| Clonality | Monoclonal |
| Target | AZ3B, HNFAG09, C3AR1, C3R1, C3a-R, C3a anaphylatoxin chemotactic receptor, C3AR |
| Endotoxin level | Please contact with the lab for this information. |
| Associated products | Mouse IgG2a Recombinant Isotype Control Antibody (C1.18.4), PerCP |
| Accession | Q16581 |
| Form | Liquid |
| Storage buffer | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| Background | C3a anaphylatoxin chemotactic receptor (C3AR1) is a ~53 kDa protein. Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a, stimulating chemotaxis, granule enzyme release and superoxide anion production. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. C3AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase. 1. Gao, J. et al. (2003) The Journal of biological chemistry 278, 37902-8. PMID: 12871936 2. Yadav, MK. et al. (2023) Cell 186, 4956-4973.e21. PMID: 37852260 3. Ames, RS. et al. (1996) The Journal of biological chemistry 271, 20231-4. PMID: 8702752 |
| Note | For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only. |




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