Anti-Mouse EGFR/ERBB1 Antibody (SAA2220) (MF004107)

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Catalog No.	MF004107
Description	Anti-Mouse EGFR/ERBB1 Antibody (SAA2220) [SAA2220] (MF004107) is a rabbit monoclonal antibody detecting ERBB1 in ELISA, FCM, IHC, WB. Suitable for Mouse. Highlights ●Rabbit Monoclonal — High specificity, affinity, and excellent lot-to-lot consistency. ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Mouse
Applications	ELISA, FCM, IHC, WB
Host species	Rabbit
Isotype	IgG
Clone ID	SAA2220
Clonality	Monoclonal
Target	Epidermal growth factor receptor, EC:2.7.10.1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1, EGFR, ERBB, ERBB1, HER1
Endotoxin level	Please contact with the lab for this information.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q01279
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Epidermal growth factor receptor (EGFR/ERBB1) is a ~134 kDa protein. Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. EGFR is the therapeutic target of cetuximab (Erbitux) and panitumumab (Vectibix). 1. Fazioli, F. et al. (1993) The EMBO journal 12, 3799-808. PMID: 8404850 2. Peng, SC. et al. (2010) Nucleic acids research 38, 7446-57. PMID: 20639532 3. Eagles, DA. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119. PMID: 35131940
Note	For research use only.

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SDS-PAGE for Anti-Mouse EGFR/ERBB1 Antibody (SAA2220)

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Datasheet

Anti-Mouse EGFR/ERBB1 Antibody (SAA2220).pdf

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Anti-Mouse EGFR/ERBB1 Antibody (SAA2220) (MF004107)

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