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InVivoMAb Anti-Human SNCA Antibody (Iv0175) (HW755040)

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InVivoMAb Anti-Human SNCA Antibody (Iv0175)

InVivoMAb Anti-Human SNCA Antibody (Iv0175)

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100ug
1mg

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Datasheet

Overview

Catalog No.	HW755040
Description	InVivoMAb Anti-Human SNCA Antibody (Iv0175) [Iv0175] (HW755040) is a mouse monoclonal antibody detecting Alpha-synuclein in ELISA, IHC, Neutralization, WB. Suitable for Human. Highlights ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, IHC, Neutralization, WB
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	Iv0175
Clonality	Monoclonal
Target	Alpha-synuclein, PARK1, Non-A4 component of amyloid precursor, NACP, Non-A beta component of AD amyloid, SNCA
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P37840
RRID	InVivoMAb Anti-Human SNCA Antibody (Iv0175) (abinScience Cat# HW755040, RRID:AB_3727149)
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Alpha-synuclein (SNCA) is a ~14 kDa protein. Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. 1. Burré, J. et al. (2010) Science (New York, N.Y.) 329, 1663-7. PMID: 20798282 2. Butler, B. et al. (2015) The Journal of biological chemistry 290, 29542-54. PMID: 26442590 3. Logan, T. et al. (2017) Nature neuroscience 20, 681-689. PMID: 28288128 4. Huang, CC. et al. (2018) Journal of cell science 131. PMID: 30404828
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Human SNCA Antibody (Iv0175).

References

Datasheet

InVivoMAb Anti-Human SNCA Antibody (Iv0175).pdf

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InVivoMAb Anti-Human SNCA Antibody (Iv0175)