| Catalog No. | HV426026 |
|---|
| Species reactivity | Human |
|---|
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
|---|
| Host species | Humanized |
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| Isotype | IgG1-kappa |
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| Expression system |
Mammalian Cells |
| Clonality |
Monoclonal |
| Target |
DPEP3, Dipeptidase 3 |
| Endotoxin level |
Please contact the lab for this information. |
| Purity |
>95% purity as determined by SDS-PAGE. |
| Purification |
Protein A/G purified from cell culture supernatant. |
| Accession |
Q9H4B8 |
| Form |
Liquid |
| Storage buffer |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternate Names | DC-1728001, SC-003, SC-003ADC, SC-003mAb, SC-Mab003, SC34.28ss1, Tamrintamabpamozirine, 2148325-59-9 |
|---|
| Background | Technetium (99mTc) pintumomab (INN) is a mouse monoclonal antibody for the imaging of adenocarcinoma. It is labelled with the radioisotope technetium-99m.
• ADC: a deadly killer of platinum resistant ovarian cancer., PMID:39367438
• A mini-overview of antibody-drug conjugates in platinum-resistant ovarian cancer: A preclinical and clinical perspective., PMID:39922351
• Molecular characterization and expression of dipeptidase 3, a testis-specific membrane-bound dipeptidase: complex formation with TEX101, a germ-cell-specific antigen in the mouse testis., PMID:21724266
• Structure of human DPEP3 in complex with the SC-003 antibody Fab fragment reveals basis for lack of dipeptidase activity., PMID:32325220
• Tamrintamab pamozirine (SC-003) in patients with platinum-resistant/refractory ovarian cancer: Findings of a phase 1 study., PMID:32513564
• The testis-specifically expressed Dpep3 is not essential for male fertility in mice., PMID:31212048
• Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies., PMID:30097533
• Effects of varicocele and microsurgical varicocelectomy on the metabolites in semen., PMID:35338186
• Identification of two additional members of the membrane-bound dipeptidase family., PMID:12738806
|
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| Note |
For research use only. Not suitable for clinical or therapeutic use. |
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