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Research Grade Enoticumab (HV571026)

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Research Grade Enoticumab

Research Grade Enoticumab

Research Grade Enoticumab

Research Grade Enoticumab

Research Grade Enoticumab

Research Grade Enoticumab

Research Grade Enoticumab

Research Grade Enoticumab

Price(USD): $

Spec:

100ug
1mg

Number:

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Overview
Images
References
Datasheet

Overview

Catalog No.	HV571026
Description	Enoticumab (HV571026) is a research-grade recombinant antibody targeting Delta-like protein 4. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	Delta-like protein 4, Drosophila Delta homolog 4, Delta4, DLL4
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9NR61
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	REGN-421, SAR153192, 1192578-27-0
Background	Delta-like protein 4 (DLL4) is a ~74 kDa protein. Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. 1. Yoneya, T. et al. (2001) Journal of biochemistry 129, 27-34. PMID: 11134954 2. Brütsch, R. et al. (2010) Circulation research 107, 592-601. PMID: 20616313 3. Del Barrio, MG. et al. (2007) Development (Cambridge, England) 134, 3427-36. PMID: 17728344
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

SEC-HPLC

SEC-HPLC detection for Research Grade Enoticumab.
Bioactivity

Detects DLL4 in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Enoticumab.
Western blot

Western blot analysis was performed using anti-DLL4 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human DLL4 (Catalog No: HV571011)
Lane 2: negative control

References

Datasheet

Research Grade Enoticumab.pdf

Formula

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Research Grade Enoticumab