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Research Grade Flanvotumab (HB884016)

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Research Grade Flanvotumab

Research Grade Flanvotumab

Research Grade Flanvotumab

Research Grade Flanvotumab

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Spec:

100ug
1mg

Number:

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Overview
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References
Datasheet

Overview

Catalog No.	HB884016
Description	Flanvotumab (HB884016) is a research-grade recombinant antibody targeting 5. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	5, 6-dihydroxyindole-2-carboxylic acid oxidase, Glycoprotein 75, CAS2, TYRP1, TRP-1, TYRRP, TRP1, Catalase B, TYRP, Melanoma antigen gp75, TRP, DHICA oxidase, Tyrosinase-related protein 1
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P17643
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	20D7S, IMC-20D7S, 1188277-05-5
Background	5,6-dihydroxyindole-2-carboxylic acid oxidase (TYRP1) is a ~60 kDa protein. Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. 1. Rooryck, C. et al. (2006) Pigment cell research 19, 239-42. PMID: 16704458 2. Kenny, EE. et al. (2012) Science (New York, N.Y.) 336, 554. PMID: 22556244 3. Simeonov, DR. et al. (2013) Human mutation 34, 827-35. PMID: 23504663 4. Lai, X. et al. (2017) Angewandte Chemie (International ed. in English) 56, 9812-9815. PMID: 28661582
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

Bioactivity

SEC-HPLC detection for Research Grade Flanvotumab.
SDS-PAGE

SDS-PAGE for Research Grade Flanvotumab.

References

Datasheet

Research Grade Flanvotumab.pdf

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Research Grade Flanvotumab