| Catalog No. | HC424016 |
|---|
| Species reactivity | Human |
|---|
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Humanized |
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| Isotype | IgG1-kappa |
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| Expression system |
Mammalian Cells |
| Clonality |
Monoclonal |
| Target |
SLC39A6, LIV1, Zrt- and Irt-like protein 6, Zinc transporter ZIP6, ZIP-6, Estrogen-regulated protein LIV-1, Solute carrier family 39 member 6, ZIP6 |
| Endotoxin level |
Please contact the lab for this information. |
| Purity |
>95% purity as determined by SDS-PAGE. |
| Purification |
Protein A/G purified from cell culture supernatant. |
| Accession |
Q13433 |
| Form |
Liquid |
| Storage buffer |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternate Names | hLIV22, SGN-LIV1A, 1629760-28-6 |
|---|
| Background | Ladiratuzumab (hLIV22) is an anti-LIV-1/ZIP6 humanized monoclonal antibody. Ladiratuzumab, conjugated with the microtubule disrupting agent, MMAE to compose SGN-LIV1A, an antibody-drug conjugate (ADC). Ladiratuzumab can be used for research of breast cancer.
• Zinc and cancer: implications for LIV-1 in breast cancer., PMID:22852056
• Recombinant Expression of Zinc Transporter SLC39A6 and Its Functional Antibody Production., PMID:31009334
• Zip6 (LIV-1) regulates zinc uptake in neuroblastoma cells under resting but not depolarizing conditions., PMID:18272141
• A mechanism for epithelial-mesenchymal transition and anoikis resistance in breast cancer triggered by zinc channel ZIP6 and STAT3 (signal transducer and activator of transcription 3)., PMID:23919497
• Concordant correlation of LIV-1 and E-cadherin expression in human breast cancer cell MCF-7., PMID:18330719
• Zip6-attenuation promotes epithelial-to-mesenchymal transition in ductal breast tumor (T47D) cells., PMID:19852955
• Microarray analyses of oral punch biopsies from acute myeloid leukemia (AML) patients treated with chemotherapy., PMID:21862359
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| Note |
For research use only. Not suitable for clinical or therapeutic use. |
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