Anti-Human CD276/B7-H3 & CD3 epsilon Bispecific Reference Antibody (Obrindatamab, RUO) (HV612046)

Name: Anti-Human CD276/B7-H3 & CD3 epsilon Bispecific Reference Antibody (Obrindatamab, RUO)
Brand: abinScience
SKU: HV612046
Price: 220 USD
Availability: InStock

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Overview

Catalog No.	HV612046
Description	Obrindatamab (HV612046) is a research-grade recombinant antibody targeting CD276. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Host species	Human
Clonality	Monoclonal
Isotype	scFv with Domain Crossover, Kappa;Lambda
Tested applications	WB
Target	4Ig-B7-H3, B7 homolog 3, B7-H3, B7H3, CD276, CD276 antigen, Costimulatory molecule, CD3E, CD3e, T-cell surface antigen T3/Leu-4 epsilon chain, T-cell surface glycoprotein CD3 epsilon chain, T3E
Endotoxin level	< 10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q5ZPR3 & P07766
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Bispecific, MGD009, RES281M1.1, hBRCA84D-hXR32-MP3M1.1, 2069959-72-2
Background	Obrindatamab is a humanized anti-B7-H3/CD3 bispecific antibody. Obrindatamab binds to B7-H3 and CD3, thereby mediating redirected cytotoxic T-lymphocyte (CTL) activity against B7-H3-expressing cancer cells. Obrindatamab can be used in research of cancer.
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

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SDS-PAGE

SDS-PAGE for Research Grade Obrindatamab
Bioactivity

Detects CD276 in indirect ELISAs.
Bioactivity

Detects CD3E in indirect ELISAs.
Bioactivity

Detects CD276 in indirect ELISA.
Bioactivity

Detects Recombinant Human CD276 Protein, C-His (Cat No.: HV612011) in indirect ELISA.
Western blot

Western blot analysis was performed using anti-CD276 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD276 (Catalog No: HV612011)
Lane 2: negative control

References

Datasheet

Anti-Human CD276/B7-H3 & CD3 epsilon Bispecific Reference Antibody (Obrindatamab, RUO).pdf

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Formula

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Recombinant Proteins

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Anti-Human CD276/B7-H3 & CD3 epsilon Bispecific Reference Antibody (Obrindatamab, RUO) (HV612046)

Overview

Images

References

Datasheet

SDS

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