Anti-Human VEGFA & PD-1 Bispecific Reference Antibody (Ivonescimab, RUO) (HB941056)

Name: Anti-Human VEGFA & PD-1 Bispecific Reference Antibody (Ivonescimab, RUO)
Brand: abinScience
SKU: HB941056
Price: 400 USD
Availability: InStock

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Overview

Catalog No.	HB941056
Description	Ivonescimab (HB941056) is a research-grade recombinant antibody targeting CD1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa-[scFv]2
Expression system	Mammalian cells
Clonality	Monoclonal
Target	Vascular endothelial growth factor A, VPF, VEGFA, VEGF, Vascular permeability factor, VEGF-A, Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P15692 & Q15116
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	TetravalentBispecific, AK112, AK-112, AK1122428381-53-5
Background	Ivonescimab (AK112) is a PD-1/VEGF Bispecific Antibody. Ivonescimab can be used for cancer research.
Note	For research use only. Not suitable for clinical or therapeutic use.

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Bioactivity

Detects VEGF165 in indirect ELISA.
Bioactivity

Detects recombinant human PD1 (Cat No.: HS870021) in indirect ELISA.
Flow CytoMetry

Flow-cytometry using FITC anti-human VEGFA&PD1 antibody. U87 cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human VEGFA&PD1 monoclonal antibody (Catalog: HB941056, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.
Western blot

Western blot analysis was performed using anti-VEGFA/VEGF165 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human VEGFA/VEGF165 (Catalog No: HB941011)
Lane 2: negative control
Flow cytometry

Flow-cytometry using anti-human VEGFA antibody. Hela cells were stained with an irrelevant antibody (Blue Histogram) or an anti-human VEGFA monoclonal antibody (Catalog HB941056, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, bound antibody was detected using a Goat Anti-Human IgG H&L Polyclonal Antibody, FITC (abinScience: HF690414) and cells analysed on a NovoCyte Flow Cytometer.
SDS-PAGE

SDS-PAGE for Research Grade Ivonescimab

References

Datasheet

Anti-Human VEGFA & PD-1 Bispecific Reference Antibody (Ivonescimab, RUO).pdf

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Recombinant Proteins

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Anti-Human VEGFA & PD-1 Bispecific Reference Antibody (Ivonescimab, RUO) (HB941056)

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Datasheet

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