| Catalog No. | HB774016 |
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| Species reactivity | Human |
|---|
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Humanized |
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| Isotype | IgG1-kappa |
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| Expression system |
Mammalian Cells |
| Clonality |
Monoclonal |
| Target |
PAUF |
| Endotoxin level |
Please contact the lab for this information. |
| Purity |
>95% purity as determined by SDS-PAGE. |
| Purification |
Protein A/G purified from cell culture supernatant. |
| Accession |
Q96DA0 |
| Form |
Liquid |
| Storage buffer |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
| Alternate Names | PBP1510, PBP-1510, PBP15102415259-90-2 |
|---|
| Background | Ulenistamab (PBP1510) is a first-in-class hunamised IgG1 monoclonal antibody targeting pancreatic adenocarcinoma upregulated factor (PAUF). Ulenistamab can be used for pancreatic cancer (PC) research.
• PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-κB Signaling Pathway., PMID:36232715
• PAUF as a Target for Treatment of High PAUF-Expressing Ovarian Cancer., PMID:35600865
• PAUF/ZG16B promotes colorectal cancer progression through alterations of the mitotic functions and the Wnt/β-catenin pathway., PMID:31095674
• Direct trafficking pathways from the Golgi apparatus to the plasma membrane., PMID:32317144
• Sorting secretory proteins., PMID:37997893
• PAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase., PMID:21464589
• PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression., PMID:19784070
• TGF-β-Induced PAUF Plays a Pivotal Role in the Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cell Line Panc-1., PMID:39518973
• A PAUF-neutralizing antibody targets both carcinoma and endothelial cells to impede pancreatic tumor progression and metastasis., PMID:25450371
• Pancreatic Adenocarcinoma Up-Regulated Factor (PAUF) Transforms Human Monocytes into Alternative M2 Macrophages with Immunosuppressive Action., PMID:39519098
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| Note |
For research use only. Not suitable for clinical or therapeutic use. |
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