Anti-Human 4-1BB/TNFRSF9/CD137 Reference Antibody (AGEN 2373, RUO) (HC336106)

Name: Anti-Human 4-1BB/TNFRSF9/CD137 Reference Antibody (AGEN 2373, RUO)
Brand: abinScience
SKU: HC336106
Price: 370 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.	HC336106
Description	Anti-Human 4-1BB/TNFRSF9/CD137 Reference Antibody (AGEN 2373, RUO) (HC336106) is a human monoclonal antibody detecting 4-1BB Ligand/TNFSF9.
Species reactivity	Human
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Host species	Human
Clonality	Monoclonal
Isotype	IgG
Clone ID	AGEN 2373
Target	4-1BB ligand receptor, CD137, CDw137, ILA, T-cell antigen 4-1BB homolog, T-cell antigen ILA, TNFRSF9, Tumor necrosis factor receptor superfamily member 9
Endotoxin level	< 10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q07011
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	AGEN2373, AGEN-2373, AGEN2373
Background	Tumor necrosis factor receptor superfamily member 9 (CD137/4-1BB) is a ~27 kDa protein. Receptor for TNFSF9/4-1BBL. Conveys a signal that enhances CD8(+) T-cell survival, cytotoxicity, and mitochondrial activity, thereby promoting immunity against viruses and tumors (Probable).
References	1. Claire Galand, et al., AGEN2373 is a conditionally-active agonist antibody targeting the co-stimulatory receptor CD137 for the treatment of human malignancies. Journal of Clinical Oncology, 2019. [HC336106]
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1, lambda Isotype Control antibody (HyHEL-10) (HP248107)

Images

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD137/TNFRSF9/4-1BB (AGEN 2373)
Bioactivity

Detects recombinant human CD137/TNFRSF9 (Catalog No: HC336011) in indirect ELISA
Immunofluorescence

Immunofluorescence staining of HDLM2 with Human monoclonal antibody (20ug/ml, overnight at 4°C), followed by Alexa Fluor-488-conjugated secondary antibody (6.5ug/ml, 50minutes at room temperature). The target protein was detected in the cell membrane.