Research Grade Altrakincept (HY457046)

Name: Research Grade Altrakincept
Brand: abinScience
SKU: HY457046
Price: 424 USD
Availability: InStock

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Overview

Catalog No.	HY457046
Description	Altrakincept (HY457046) is a research-grade recombinant antibody targeting Binetrakin. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Functional assay, Research in vivo
Isotype	Fusion - [IL4R(Interleukin-4 receptor subunit alpha, IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA)]
Expression system	Mammalian cells
Target	Binetrakin, B-cell stimulatory factor 1, Pitrakinra, Lymphocyte stimulatory factor 1, IL-4, BSF-1, IL4, Interleukin-4
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Purified by ion exchange chromatography.
Accession	P05112
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	Nuvance
Background	Interleukin-4 (IL4) is a ~17 kDa protein. Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1. Also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. 1. Carr, C. et al. (1991) Biochemistry 30, 1515-23. PMID: 1993171 2. Yokota, T. et al. (1986) Proceedings of the National Academy of Sciences of the United States of America 83, 5894-8. PMID: 3016727 3. Delespesse, G. et al. (1989) Journal of immunology (Baltimore, Md. : 1950) 142, 134-8. PMID: 2521231 4. Hage, T. et al. (1999) Cell 97, 271-81. PMID: 10219247 5. Hülsmeyer, M. et al. (2001) Acta crystallographica. Section D, Biological crystallography 57, 1334-6. PMID: 11526337 6. LaPorte, SL. et al. (2008) Cell 132, 259-72. PMID: 18243101 7. Malabarba, MG. et al. (1995) The Journal of biological chemistry 270, 9630-7. PMID: 7721895
Note	For research use only. Not suitable for clinical or therapeutic use.