Research Grade Anti-Human KLB/Beta-klotho Antibody (MK-3655) (HV266026)

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100ug
1mg

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Overview

Catalog No.	HV266026
Description	Anti-Human KLB/Beta-klotho Antibody (MK-3655) (HV266026) is a research-grade recombinant antibody targeting Klotho beta-like protein. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Mouse
Isotype	IgG2a-kappa
Clone ID	MK-3655
Expression system	Mammalian Cells
Clonality	Monoclonal
Target	Klotho beta-like protein, KLB, Beta-klotho, BetaKlotho, BKL
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q86Z14
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names	MK-3655, NGM-313, NGM313
Background	Beta-klotho (KLB) is a ~119 kDa protein. Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21.
Note	For research use only. Not suitable for clinical or therapeutic use.