| Catalog No. | HY171066 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Chimeric |
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| Isotype | IgG4-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | Plasma thromboplastin antecedent, PTA, Coagulation factor XI, F11, FXI |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P03951 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | 2704554-77-6 |
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| Background | Gruticibart is an anti-F11 human IgG4 κ monoclonal antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
• Factor XI deficiency., PMID:18312365
• How to Capture the Bleeding Phenotype in FXI-Deficient Patients., PMID:33003209
• Plasma Kallikrein Contributes to Coagulation in the Absence of Factor XI by Activating Factor IX., PMID:31766871
• Factor XI promotes hemostasis in factor IX-deficient mice., PMID:30007049
• Heterozygote carriers of mutations in the F11 gene, encoding Factor XI, have normal coagulation by thromboelastography during pregnancy., PMID:31791878
• Regulation of coagulation factor XI expression by microRNAs in the human liver., PMID:25379760
• Gene Variants in Two Families with Inherited Coagulation Factor XI Deficiency and Identification of Mutations., PMID:36543159
• Factor 11 single-nucleotide variants in women with heavy menstrual bleeding., PMID:28609141
• Essential role of a carboxyl-terminal α-helix motif in the secretion of coagulation factor XI., PMID:33421272
• Activity of coagulation factor XI in patients with spontaneous miscarriage: the presence of risk alleles., PMID:25517908
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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