| Catalog No. | HC570016 |
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| Species reactivity | Human |
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| Applications | ELISA, Functional assay, Research in vivo |
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| Isotype | Human ACTR-IIB extracellular domain (ECD) fragment fused via the peptide linker to a human IgG1 Fc fragment |
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| Expression system | Mammalian Cells |
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| Target | ACTR-IIB, Activin receptor type IIB, Activin receptor type-2B, ACVR2B |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | Q13705 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | 2769700-97-0 |
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| Background | Cibotercept is an anti-MSTN/INHBA/GDF11 monoclonal antibody.
• LncRNA ACVR2B-as1 interacts with ALDOA to regulate the self-renewal and apoptosis of human spermatogonial stem cells by controlling glycolysis activity., PMID:39254854
• Epistasis between polymorphisms in ACVR2B and ADAMTS19 is associated with premature ovarian failure., PMID:25051287
• ACVR2B/Fc counteracts chemotherapy-induced loss of muscle and bone mass., PMID:29089584
• Activin A and Acvr2b mRNA from Umbilical Cord Blood Are Not Reliable Markers of Mild or Moderate Neonatal Hypoxic-Ischemic Encephalopathy., PMID:33706404
• Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B., PMID:26047946
• iMSC-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva., PMID:38500216
• BMPR2 inhibits activin and BMP signaling via wild-type ALK2., PMID:29739878
• Circ_0000566 contributes oxygen-glucose deprivation and reoxygenation (OGD/R)-induced human brain microvascular endothelial cell injury via regulating miR-18a-5p/ACVR2B axis., PMID:36781583
• Muscle and serum metabolomes are dysregulated in colon-26 tumor-bearing mice despite amelioration of cachexia with activin receptor type 2B ligand blockade., PMID:30860875
• Antibody-based strategies for the detection of Luspatercept (ACE-536) in human serum., PMID:28929587
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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