| Catalog No. | HB771016 |
|---|
| Species reactivity | Human |
|---|
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
|---|
| Host species | Humanized |
|---|
| Isotype | IgG1-kappa |
|---|
| Expression system |
Mammalian Cells |
| Species |
Human |
| Clonality |
Monoclonal |
| Target |
T-cell growth factor P40, Cytokine P40, IL9, Interleukin-9, IL-9 |
| Endotoxin level |
Please contact with the lab for this information. |
| Purity |
>95% as determined by SDS-PAGE. |
| Purification |
Protein A/G purified from cell culture supernatant. |
| Accession |
P15248 |
| Form |
Liquid |
| Storage buffer |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| Alternate Names | 7F3com-2H2, MEDI-528, 909875-08-7 |
|---|
| Background | Enokizumab (MEDI-528) is a monoclonal antibody targeting to interleukin (IL)-9. IL-9 regulates the development of airway inflammation, mucus production, airway hyperresponsiveness, and airway fibrosis largely by increasing mast cell numbers and activity in the airways.
• IL-9 secreted by leukemia stem cells induces Th1-skewed CD4+ T cells, which promote their expansion., PMID:38941612
• Positive feedback loop PU.1-IL9 in Th9 promotes rheumatoid arthritis development., PMID:39164066
• The Role of Interleukin-9 in Cancer., PMID:31016637
• IL-9, a local growth factor for synovial T cells in inflammatory arthritis., PMID:26751012
• Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease., PMID:38825637
• Interleukin-9 and mast cells., PMID:23034251
• IL-9 sensitizes human TH2 cells to proinflammatory IL-18 signals in atopic dermatitis., PMID:39521283
• IL-9 and IL-9-producing cells in tumor immunity., PMID:32228589
• Interleukin-9 and T helper type 9 cells in rheumatic diseases., PMID:27159882
• IL-9-producing T cells: potential players in allergy and cancer., PMID:32788707
|
|---|
| Note |
For research use only. Not suitable for clinical or therapeutic use. |
中文
English
