Anti-Human ANGPTL3 Reference Antibody (Rivocibart, RUO) (HV176026)

Name: Anti-Human ANGPTL3 Reference Antibody (Rivocibart, RUO)
Brand: abinScience
SKU: HV176026
Price: 370 USD
Availability: InStock

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100ug
1mg

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Overview

Catalog No.	HV176026
Description	Anti-Human ANGPTL3 Reference Antibody (Rivocibart, RUO) (HV176026) is a human monoclonal antibody detecting ANGPTL3.
Species reactivity	Human
Applications	ELISA, FCM, Functional assay
Host species	Human
Clonality	Monoclonal
Isotype	IgG4, kappa
Expression system	Mammalian cells
Nature	Recombinant
Target	ANG-5, ANGPT5, ANGPTL3, ANGPTL3(17-221), ANGPTL3(17-224), Angiopoietin-5, Angiopoietin-like protein 3, Angiopoietin-related protein 3
Endotoxin level	< 10 EU/mg as determined by LAL method.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9Y5C1
Form	Liquid
Storage buffer	0.01M PBS pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term from the date of receipt..
Alternate Names	CAS: 3067651-10-6
Background	Angiopoietin-related protein 3 (ANGPTL3) is a ~53 kDa protein. Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism. Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake. Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface; the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and is not inhibited by GPIHBP1. Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids. 1. Koishi, R. et al. (2002) Nature genetics 30, 151-7. PMID: 11788823 2. Ono, M. et al. (2003) The Journal of biological chemistry 278, 41804-9. PMID: 12909640 3. Robciuc, MR. et al. (2013) Arteriosclerosis, thrombosis, and vascular biology 33, 1706-13. PMID: 23661675 4. Tikka, A. et al. (2014) Bioscience reports 34, e00160. PMID: 25495645 5. Shimizugawa, T. et al. (2002) The Journal of biological chemistry 277, 33742-8. PMID: 12097324 6. Lee, EC. et al. (2009) The Journal of biological chemistry 284, 13735-13745. PMID: 19318355 7. Liu, J. et al. (2010) The Journal of biological chemistry 285, 27561-70. PMID: 20581395 8. Shimamura, M. et al. (2007) Arteriosclerosis, thrombosis, and vascular biology 27, 366-72. PMID: 17110602 9. Shan, L. et al. (2009) The Journal of biological chemistry 284, 1419-24. PMID: 19028676 10. Shimamura, M. et al. (2003) Biochemical and biophysical research communications 301, 604-9. PMID: 12565906
Note	For research use only. Not suitable for clinical or therapeutic use.

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Anti-Human ANGPTL3 Reference Antibody (Rivocibart, RUO).pdf

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Anti-Human ANGPTL3 Reference Antibody (Rivocibart, RUO) (HV176026)

Overview

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