| Catalog No. | HF565026 |
|---|
| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Mouse |
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| Isotype | IgG1-nd |
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| Expression system |
Mammalian Cells |
| Species |
Human |
| Clonality |
Monoclonal |
| Target |
Interferon alpha/beta receptor 1, Cytokine receptor family 2 member 1, Cytokine receptor class-II member 1, CRF2-1, IFN-R-1, IFNAR1, IFNAR, IFN-alpha/beta receptor 1, Type I interferon receptor 1 |
| Endotoxin level |
Please contact with the lab for this information. |
| Purity |
>95% as determined by SDS-PAGE. |
| Purification |
Protein A/G purified from cell culture supernatant. |
| Accession |
P17181 |
| Form |
Liquid |
| Storage buffer |
0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
|
| Stability and Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
| Alternate Names | 64G12, 167816-91-3 |
|---|
| Background | Anifrolumab is a type I interferon (IFN) receptor antagonist, a human monoclonal antibody. Anifrolumab blocks the activity of type I interferon. Anifrolumab can be used in systemic lupus erythematosus (SLE) research.
• Herpes Simplex Virus 1 UL36USP Antagonizes Type I Interferon-Mediated Antiviral Innate Immunity., PMID:29997210
• Structure-function study of the extracellular domain of the human type I interferon receptor (IFNAR)-1 subunit., PMID:10841076
• The neutralization of type I IFN biologic actions by anti-IFNAR-2 monoclonal antibodies is not entirely due to inhibition of Jak-Stat tyrosine phosphorylation., PMID:11096454
• ITAM-coupled receptors inhibit IFNAR signaling and alter macrophage responses to TLR4 and Listeria monocytogenes., PMID:22368279
• Influence of type-I Interferon receptor expression level on the response to type-I Interferons in human pancreatic cancer cells., PMID:24460759
• The receptor for type I IFNs is highly expressed on peripheral blood B cells and monocytes and mediates a distinct profile of differentiation and activation of these cells., PMID:14980077
• N-glycosylation of murine IFN-beta in a putative receptor-binding region., PMID:16734561
• Expression and function of RIG-I in oral keratinocytes and fibroblasts., PMID:25359319
• Vascular endothelial growth factor-induced elimination of the type 1 interferon receptor is required for efficient angiogenesis., PMID:21832278
• Differential Responsiveness of Monocyte and Macrophage Subsets to Interferon., PMID:31390156
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| Note |
For research use only. Not suitable for clinical or therapeutic use. |
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