| Catalog No. | HF909016 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Humanized |
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| Isotype | IgG2-kappa |
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| Expression system | Mammalian Cells |
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| Species | Human |
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| Clonality | Monoclonal |
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| Target | Beta-nerve growth factor, NGFB, Beta-NGF, NGF |
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| Endotoxin level | Please contact with the lab for this information. |
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| Purity | >95% as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P01138 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
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| Alternate Names | PF-04383119, RN624, 880266-57-9 |
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| Background | Luvagrobart is an anti-NGF human IgG1 κ monoclonal antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
• Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment., PMID:21358750
• Nerve growth factor R221W responsible for insensitivity to pain is defectively processed and accumulates as proNGF., PMID:19038341
• Rare human nerve growth factor-β mutation reveals relationship between C-afferent density and acute pain evaluation., PMID:27146986
• Genomic NGFB variation and multiple sclerosis in a case control study., PMID:19063739
• A novel NGFB point mutation: a phenotype study of heterozygous patients., PMID:18420729
• Variation in the BDNF and NGFB genes in German atopic dermatitis patients., PMID:19038326
• Variation in NGFB is associated with primary affective disorders in women., PMID:21294249
• Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders., PMID:18203754
• In vitro receptor binding properties of a "painless" NGF mutein, linked to hereditary sensory autonomic neuropathy type V., PMID:19945432
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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