Anti-beta-NGF Reference Antibody (Frunevetmab, RUO) (FF909016)

Name: Anti-beta-NGF Reference Antibody (Frunevetmab, RUO)
Brand: abinScience
SKU: FF909016
Price: 176 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

FF909016

Description

Research Grade Frunevetmab (FF909016) is a felinized monoclonal antibody detecting Nerve Growth Factor beta subunit in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Cat.

Highlights

●Multi-Application — Validated across multiple applications.

Species reactivity

Feline

Applications

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Host species

Feline

Isotype

IgG1-kappa

Expression system

Mammalian cells

Species

Cat

Clonality

Monoclonal

Target

Nerve Growth Factor beta subunit, ngfb

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q6ZY27

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternate Names

NV-02, 1708936-80-4

Background

Frunevetmab (NV-02) is a felinized anti-nerve growth factor (NGF) monoclonal antibody with a Kd of 20 pM. Frunevetmab can effectively decrease osteoarthritis (OA) pain in cats.
• Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment., PMID:21358750
• Synthesis of the biologically active beta-subunit of human nerve growth factor in Escherichia coli., PMID:1537563
• Nerve growth factor translates stress response and subsequent murine abortion via adhesion molecule-dependent pathways., PMID:16371592
• Two thyroid hormone regulated genes, the beta-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), are located less than 310 kb apart in both human and mouse genomes., PMID:2906326
• Nerve growth factor and the physiology of pain: lessons from congenital insensitivity to pain with anhidrosis., PMID:22882139
• A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception., PMID:14976160
• Rare human nerve growth factor-β mutation reveals relationship between C-afferent density and acute pain evaluation., PMID:27146986
• Linkage relationships of the gene for the beta subunit of nerve growth factor (NGFB) with other chromosome 1 marker loci., PMID:4006521
• Nerve growth factor exhibits an antioxidant and an autocrine activity in mouse liver that is modulated by buthionine sulfoximine, arsenic, and acetaminophen., PMID:23472850
• Assignment of the beta-nerve growth factor (NGFB) to bovine chromosome 3 band q23 by in situ hybridization., PMID:9284944

Note

For research use only. Not suitable for clinical or therapeutic use.

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