Mouse CD14 Recombinant Protein (C-Fc) (MY038011)

Name: Mouse CD14 Recombinant Protein (C-Fc)
Brand: abinScience
SKU: MY038011
Price: 298 USD
Availability: InStock

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Overview

Catalog No.	MY038011
Description	Recombinant Mouse CD14 Protein, C-Fc (MY038011) expressed in Mammalian Cells, spanning Met1-Pro345. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	Mammalian cells
Accession	P10810
Protein length	Met1-Pro345
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Mus musculus (Mouse)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	63.49 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	CD14, Monocyte differentiation antigen CD14, Monocyte differentiation antigen CD14, membrane-bound form, Monocyte differentiation antigen CD14, urinary form, My23 antigen, Myeloid cell-specific leucine-rich glycoprotein
Background	Monocyte differentiation antigen CD14 is a ~39 kDa protein. Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Acts as an accessory receptor for M.tuberculosis lipoproteins LprA, LprG and LpqH, in conjunction with coreceptors TLR2 and TLR1. 1. Gangloff, SC. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 175, 3940-5. PMID: 16148141 2. Jiang, Z. et al. (2005) Nature immunology 6, 565-70. PMID: 15895089 3. Haziot, A. et al. (1996) Immunity 4, 407-14. PMID: 8612135 4. Drage, MG. et al. (2009) Cellular immunology 258, 29-37. PMID: 19362712
Note	For research use only

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Datasheet

Mouse CD14 Recombinant Protein (C-Fc).pdf

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Mouse CD14 Recombinant Protein (C-Fc) (MY038011)

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