ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species
Murine leukemia virus (MLV)
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names
CA, Capsid protein p30, EC:2.7.7.-, EC:2.7.7.49, EC:2.7.7.7, EC:3.1.-.-, EC:3.1.26.4, EC:3.4.23.-, Gag-Pol polyprotein, IN, Integrase, MA, Matrix protein p15, NC-pol, Nucleocapsid protein p10-Pol, PR, Pr180gag-pol, Protease, RNA-binding phosphoprotein p12, RT, Reverse transcriptase/ribonuclease H, gag-pol, p14, p46, p80, pp12
Background
Gag-Pol polyprotein is a ~194 kDa protein. Plays a role in budding and is processed by the viral protease during virion maturation outside the cell. During budding, it recruits, in a PPXY-dependent or independent manner, Nedd4-like ubiquitin ligases that conjugate ubiquitin molecules to Gag-Pol, or to Gag-Pol binding host factors. Interaction with HECT ubiquitin ligases probably links the viral protein to the host ESCRT pathway and facilitates release.
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