GMP Grade Human IL-15 (CF) (HW541011)

Name: GMP Grade Human IL-15 (CF)
Brand: abinScience
SKU: HW541011
Price: 350 USD
Availability: InStock

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Overview

Catalog No.	HW541011
Description	GMP Grade Human IL-15 (CF) (HW541011) expressed in Mammalian cells. Purity: >95% as determined by SDS-PAGE. by SDS-PAGE. Highlights ●Recombinant — Consistent lot-to-lot performance. ●High Purity — >95% as determined by SDS-PAGE. by SDS-PAGE for demanding downstream applications. ●Bioactive — Verified biological activity.
Expression system	Mammalian cells
Accession	P40933
Protein length	Asn49-Ser162
Applications	ELISA, Immunogen, SDS-PAGE, WB, Activity assya
Species	Homo sapiens (Human)
Biological activity	Measured in a cell proliferation assay using CTLL-2 mouse cytotoxic T cells. The ED50 for this effect is ≤0.1 ng/mL，corresponding to a specific bioactivity of ≥ 2 x 107 units/mg.
Nature	Recombinant
Endotoxin level	<10 EU/mg
Purity	>95% as determined by SDS-PAGE.
Predicted molecular weight	12.7 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 5% Mannitol, 0.01% Tween 80. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	IL-15, IL15, Interleukin-15, IL 15
Background	Interleukin-15 (IL15) is a ~18 kDa protein. Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems. Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines. In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection. Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits. Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5. 1. Ratthé, C. et al. (2004) Journal of leukocyte biology 76, 162-8. PMID: 15123770 2. Grabstein, KH. et al. (1994) Science (New York, N.Y.) 264, 965-8. PMID: 8178155 3. Badolato, R. et al. (1997) Blood 90, 2804-9. PMID: 9326248 4. Musso, T. et al. (1999) Blood 93, 3531-9. PMID: 10233906 5. Ring, AM. et al. (2012) Nature immunology 13, 1187-95. PMID: 23104097 6. Giri, JG. et al. (1994) The EMBO journal 13, 2822-30. PMID: 8026467 7. Johnston, JA. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 8705-9. PMID: 7568001
Note	For research use only

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Datasheet

GMP Grade Human IL-15 (CF).pdf

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Formula

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GMP Grade Human IL-15 (CF) (HW541011)

Overview

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References

Datasheet

SDS