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Anti-ABCA3 Polyclonal Antibody (HV604014)

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Overview
Catalog No.HV604014
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
ClonalityPolyclonal
IsotypeIgG
Immunogen E. coli - derived recombinant Human ABCA3 (Asp1358-Phe1635).
Target ABCA3, ATP-binding cassette sub-family A member 3, Phospholipid-transporting ATPase ABCA3, ABC3, ATP-binding cassette 3, ATP-binding cassette transporter 3, ABC-C transporter, Xenobiotic-transporting ATPase ABCA3
Purification Purified by antigen affinity column.
Accession Q99758
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Phospholipid-transporting ATPase ABCA3 is a ~191 kDa protein. Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant. Transports preferentially phosphatidylcholine containing short acyl chains. In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity.

1. Matsumura, Y. et al. (2006) The Journal of biological chemistry 281, 34503-14. PMID: 16959783
2. Matsumura, Y. et al. (2007) FEBS letters 581, 3139-44. PMID: 17574245
3. Wittmann, T. et al. (2016) Pediatric pulmonology 51, 1284-1294. PMID: 27177387
4. Höppner, S. et al. (2017) Biochimica et biophysica acta. Molecular cell research 1864, 2330-2335. PMID: 28887056
5. Li, Y. et al. (2019) Biochimica et biophysica acta. Molecular and cell biology of lipids 1864, 158516. PMID: 31473345
6. Zarbock, R. et al. (2015) Biochimica et biophysica acta 1851, 987-95. PMID: 25817392
7. Dohmen, LC. et al. (2016) The Journal of biological chemistry 291, 9638-47. PMID: 26903515
Note For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-ABCA3 Polyclonal Antibody

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