Anti-ANP32A Polyclonal Antibody (HW663014)

Name: Anti-ANP32A Polyclonal Antibody
Brand: abinScience
SKU: HW663014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HW663014

Description

Anti-ANP32A Polyclonal Antibody (HW663014) is a rabbit polyclonal antibody detecting ANP32A in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ANP32A (Glu2-Asp175).

Target

pp32, Putative HLA-DR-associated protein I, MAPM, ANP32A, C15orf1, Acidic leucine-rich nuclear phosphoprotein 32 family member A, Mapmodulin, LANP, Potent heat-stable protein phosphatase 2A inhibitor I1PP2A, PHAPI, Leucine-rich acidic nuclear protein, Acidic nuclear phosphoprotein pp32, PHAP1

Purification

Purified by antigen affinity column.

Accession

P39687

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) is a ~28 kDa protein. Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition.

1. Brody, JR. et al. (1999) The Journal of biological chemistry 274, 20053-5. PMID: 10400610

2. Bai, J. et al. (2001) Oncogene 20, 2153-60. PMID: 11360199

3. Fan, Z. et al. (2006) Cell death and differentiation 13, 1485-94. PMID: 16341127

4. Kim, HE. et al. (2008) Molecular cell 30, 239-47. PMID: 18439902

5. Seo, SB. et al. (2002) The Journal of biological chemistry 277, 14005-10. PMID: 11830591

6. Mazroui, R. et al. (2008) The Journal of cell biology 180, 113-27. PMID: 18180367

7. Tsujio, I. et al. (2005) FEBS letters 579, 363-72. PMID: 15642345

8. Cvetanovic, M. et al. (2007) EMBO reports 8, 671-7. PMID: 17557114

Note

For research use only.

Images

References

Datasheet

Anti-ANP32A Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Assay Kits

Anti-ANP32A Polyclonal Antibody (HW663014)

Overview

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References

Datasheet

SDS

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