Anti-ANXA1 Polyclonal Antibody (HY216014)

Name: Anti-ANXA1 Polyclonal Antibody
Brand: abinScience
SKU: HY216014
Price: 96 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HY216014

Description

Anti-ANXA1 Polyclonal Antibody (HY216014) is a rabbit polyclonal antibody detecting ANXA1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Cavia cutleri.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ANXA1 (Met1-Asn346).

Target

LPC1, Calpactin-2, Lipocortin I, ANX1, ANXA1, Phospholipase A2 inhibitory protein, Chromobindin-9, Annexin I, Annexin A1, p35, Calpactin II, Annexin-1

Purification

Purified by antigen affinity column.

Accession

P04083

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Annexin A1 (ANXA1) is a ~38 kDa protein. Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T cells. Promotes the differentiation of T cells into Th1 cells and negatively regulates differentiation into Th2 cells.

1. Arcone, R. et al. (1993) European journal of biochemistry 211, 347-55. PMID: 8425544

2. D'Acquisto, F. et al. (2007) Blood 109, 1095-102. PMID: 17008549

3. McArthur, S. et al. (2009) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23, 4000-10. PMID: 19625660

4. Pepinsky, RB. et al. (1989) The Biochemical journal 263, 97-103. PMID: 2532504

5. Mailliard, WS. et al. (1996) The Journal of biological chemistry 271, 719-25. PMID: 8557678

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-ANXA1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Hela cell lysate
Lane 2: A431 cell lysate
Lane 3: K562 cell lysate
Lane 4: Jurkat cell lysate