Anti-ARG2 Polyclonal Antibody (HX072014)

Name: Anti-ARG2 Polyclonal Antibody
Brand: abinScience
SKU: HX072014
Price: 96 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HX072014

Description

Anti-ARG2 Polyclonal Antibody (HX072014) is a rabbit polyclonal antibody detecting ARG2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ARG2 (Val23-Ile354).

Target

Arginase-2, mitochondrial, Type II arginase, Kidney-type arginase, Arginase II, Non-hepatic arginase, ARG2

Purification

Purified by antigen affinity column.

Accession

P78540

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Arginase-2, mitochondrial (ARG2/Arginase II) is a ~38 kDa protein. May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells. May suppress inflammation-related signaling in asthmatic airway epithelium.

1. Geiger, R. et al. (2016) Cell 167, 829-842.e13. PMID: 27745970

2. Xu, W. et al. (2016) The Journal of clinical investigation 126, 2465-81. PMID: 27214549

3. McGovern, N. et al. (2017) Nature 546, 662-666. PMID: 28614294

4. Yepuri, G. et al. (2012) Aging cell 11, 1005-16. PMID: 22928666

5. Xiong, Y. et al. (2014) Autophagy 10, 2223-38. PMID: 25484082

6. Xiong, Y. et al. (2013) Journal of the American Heart Association 2, e000096. PMID: 23832324

7. Cama, E. et al. (2003) Biochemistry 42, 8445-51. PMID: 12859189

Note

For research use only.

Images

Western blot

Lane 1: K562 cell lysate
Lane 2: 293T cell lysate

References

Datasheet

Anti-ARG2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-ARG2 Polyclonal Antibody (HX072014)

Overview

Images

References

Datasheet

SDS

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