Anti-ASIC2A Recombinant Antibody (N412A/55) (HS947023)

Name: Anti-ASIC2A Recombinant Antibody (N412A/55)
Brand: abinScience
SKU: HS947023
Price: 196 USD
Availability: InStock

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100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HS947023

Description

Anti-ASIC2A Recombinant Antibody (N412A/55) (HS947023) is a mouse monoclonal antibody detecting ASIC2 in IHC, WB.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Applications

IHC, WB

Host species

Mouse

Clonality

Monoclonal

Isotype

IgG2a, kappa

Clone ID

N412A/55

Target

BNaC1, ACCN, ACCN1, Mammalian degenerin homolog, Acid-sensing ion channel 2, BNAC1, MDEG, Amiloride-sensitive brain sodium channel, Amiloride-sensitive cation channel 1, neuronal, ASIC2, Brain sodium channel 1, Amiloride-sensitive cation channel neuronal 1, BNC1

Endotoxin level

< 10 EU/mg as determined by LAL method.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

RRID

Anti-ASIC2A Antibody (N412A/55) (abinScience Cat# HS947023, RRID:AB_3728439)
_x005F_x000D_

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Acid-sensing ion channel 2 (ASIC2) is a ~57 kDa protein. Forms pH-gated trimeric sodium channels that act as postsynaptic excitatory sensors in the nervous system. Upon extracellular acidification, these channels generate rapid, transient inward currents that fully desensitize. Highly selective for sodium, they are permeable to other cations. By forming heterotrimeric channels with ASIC1, could contribute to synaptic plasticity, learning, and memory. Additionally, as acid sensors at nerve terminals, plays a role in mechanosensation and phototransduction.

1. Babinski, K. et al. (2000) The Journal of biological chemistry 275, 28519-25. PMID: 10842183

2. Diochot, S. et al. (2012) Nature 490, 552-5. PMID: 23034652

3. Price, MP. et al. (1996) The Journal of biological chemistry 271, 7879-82. PMID: 8626462

4. Waldmann, R. et al. (1996) The Journal of biological chemistry 271, 10433-6. PMID: 8631835

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-ASIC2A Antibody (N412A/55)

References

Datasheet

Anti-ASIC2A Recombinant Antibody (N412A/55).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-ASIC2A Recombinant Antibody (N412A/55) (HS947023)

Overview

Images

References

Datasheet

SDS