Anti-C1QBP Polyclonal Antibody (HC372014)

Name: Anti-C1QBP Polyclonal Antibody
Brand: abinScience
SKU: HC372014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HC372014

Description

Anti-C1QBP Polyclonal Antibody (HC372014) is a rabbit polyclonal antibody detecting C1QBP in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human C1QBP (Thr76-Gln282).

Target

Hyaluronan-binding protein 1, SF2AP32, C1QBP, gC1q-R protein, SF2P32, Glycoprotein gC1qBP, Complement component 1 Q subcomponent-binding protein, mitochondrial, ASF/SF2-associated protein p32, GC1QBP, HABP1, p33, C1qBP, Mitochondrial matrix protein p32

Purification

Purified by antigen affinity column.

Accession

Q07021

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) is a ~31 kDa protein. Multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation.

1. Petersen-Mahrt, SK. et al. (1999) The EMBO journal 18, 1014-24. PMID: 10022843

2. Joseph, K. et al. (1999) Clinical immunology (Orlando, Fla.) 92, 246-55. PMID: 10479529

3. Nguyen, T. et al. (2000) Infection and immunity 68, 2061-8. PMID: 10722602

4. Kittlesen, DJ. et al. (2000) The Journal of clinical investigation 106, 1239-49. PMID: 11086025

5. Feng, X. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 2441-8. PMID: 11859136

6. Chattopadhyay, C. et al. (2004) Nucleic acids research 32, 3632-41. PMID: 15243141

7. Vegh, Z. et al. (2006) Molecular immunology 43, 1402-7. PMID: 16140380

8. Waggoner, SN. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 175, 4706-14. PMID: 16177118

9. Waggoner, SN. et al. (2007) Journal of leukocyte biology 82, 1407-19. PMID: 17881511

10. Huang, L. et al. (2008) Investigative ophthalmology & visual science 49, 5243-9. PMID: 18676636

Note

For research use only.

Images

References

Datasheet

Anti-C1QBP Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-C1QBP Polyclonal Antibody (HC372014)

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Datasheet

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