Anti-CD121a/IL1R1 Polyclonal Antibody (HB791014)

Name: Anti-CD121a/IL1R1 Polyclonal Antibody
Brand: abinScience
SKU: HB791014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HB791014

Description

Anti-CD121a/IL1R1 Polyclonal Antibody (HB791014) is a rabbit polyclonal antibody detecting CD121a in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD121a/IL1R1 (Asp21-Ile109).

Target

IL-1RT1, IL-1R-alpha, mIL-1R1, CD121a, IL-1R-1, sIL-1RI, IL1RT1, IL1R1, sIL-1R1, IL1R, CD121 antigen-like family member A, Interleukin-1 receptor type I, Interleukin-1 receptor alpha, mIL-1RI, IL1RA, IL-1RT-1, Interleukin-1 receptor type 1, p80

Purification

Purified by antigen affinity column.

Accession

P14778

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Interleukin-1 receptor type 1 (CD121a/IL1R1) is a ~65 kDa protein. Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells.

1. Mosley, B. et al. (1987) The Journal of biological chemistry 262, 2941-4. PMID: 2950091

2. Wang, Y. et al. (2023) Immunity 56, 1485-1501.e7. PMID: 37315560

3. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850

Note

For research use only.

Images

Western blot

Western blot analysis was performed using anti-CD121a/IL1R1 polyclonal antibody at 1ug/mL on recombinant CD121a/IL1R1 (Catalog No. HB791012).

References

Datasheet