

| Catalog No. | HY248307 |
|---|---|
| Description |
Anti-CD29/ITGB1 Antibody (AIIB2) [AIIB2] (HY248307) is a mouse monoclonal antibody detecting ITGB1 in ELISA, FCM, FuncS, ICC, IF, IHC, IP, WB. Suitable for Human.
Highlights
|
| Species reactivity | Human |
| Applications | ELISA, FCM, FuncS, ICC, IF, IHC, IP, WB |
| Host species | Mouse |
| Isotype | IgG2a |
| Clone ID | AIIB2 |
| Clonality | Monoclonal |
| Target | CD29, FNRB, Fibronectin receptor subunit beta, GPIIA, Glycoprotein IIa, ITGB1, Integrin beta-1, MDF2, MSK12, VLA-4 subunit beta |
| Endotoxin level | <10 EU/mg |
| Purity | >95% as determined by SDS-PAGE. |
| Purification | Protein A/G purified from cell culture supernatant. |
| Accession | P05556 |
| Form | Liquid |
| Storage buffer | 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Background | Integrin beta-1 (CD29/ITGB1) is a ~88 kDa protein. Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. 1. Fujita, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 5809-19. PMID: 23125415 2. Fujita, M. et al. (2014) PloS one 9, e96372. PMID: 24789099 3. Saegusa, J. et al. (2008) The Journal of biological chemistry 283, 26107-15. PMID: 18635536 4. Fujita, M. et al. (2015) The Journal of biological chemistry 290, 259-71. PMID: 25398877 5. Bax, DV. et al. (2003) The Journal of biological chemistry 278, 34605-16. PMID: 12807887 6. Jovanovic, J. et al. (2007) The Journal of biological chemistry 282, 6743-51. PMID: 17158881 7. Schumacher, S. et al. (2021) Science advances 7. PMID: 33962943 8. Takada, YK. et al. (2017) The Journal of biological chemistry 292, 20067-20075. PMID: 29030430 9. Takada, YK. et al. (2019) Journal of immunology (Baltimore, Md. : 1950) 203, 1383-1391. PMID: 31331973 10. Morris, GE. et al. (2022) British journal of pharmacology 179, 4958-4973. PMID: 35802072 |
| Note | For research use only |




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