Anti-CD2AP Polyclonal Antibody (HV416014)

Name: Anti-CD2AP Polyclonal Antibody
Brand: abinScience
SKU: HV416014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HV416014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CD2AP (Val2-Lys58).

Target

CD2-associated protein, Adapter protein CMS, Cas ligand with multiple SH3 domains, CD2AP

Purification

Purified by antigen affinity column.

Accession

Q9Y5K6

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

CD2-associated protein (CD2AP) is a ~71 kDa protein. Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus.

1. Kirsch, KH. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 6211-6. PMID: 10339567

2. Monzo, P. et al. (2005) Molecular biology of the cell 16, 2891-902. PMID: 15800069

3. Elbediwy, A. et al. (2012) The Journal of cell biology 198, 677-93. PMID: 22891260

Note

For research use only.

Images

References

Datasheet

Anti-CD2AP Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-CD2AP Polyclonal Antibody (HV416014)

Overview

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References

Datasheet

SDS

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