Anti-Human CD2AP Monoclonal Antibody (1A674) (HV416015)

Name: Anti-Human CD2AP Monoclonal Antibody (1A674)
Brand: abinScience
SKU: HV416015
Price: 106 USD
Availability: InStock

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Catalog No.	HV416015
Description	Anti-Human CD2AP Monoclonal Antibody (1A674) [1A674] (HV416015) is a mouse monoclonal antibody detecting CD2AP in ELISA, IHC, WB. Suitable for Human. Highlights ●Recombinant — Superior batch-to-batch reproducibility with defined sequences. ●Multi-Application — Validated across multiple applications.
Species reactivity	Human
Applications	ELISA, IHC, WB
Host species	Mouse
Isotype	IgG
Clone ID	1A674
Clonality	Monoclonal
Immunogen	E. coli - derived recombinant human CD2AP (Val2-Lys58).
Target	CD2-associated protein, Adapter protein CMS, Cas ligand with multiple SH3 domains, CD2AP
Purification	Protein A/G purified from cell culture supernatant.
Accession	Q9Y5K6
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	CD2-associated protein (CD2AP) is a ~71 kDa protein. Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. 1. Kirsch, KH. et al. (1999) Proceedings of the National Academy of Sciences of the United States of America 96, 6211-6. PMID: 10339567 2. Monzo, P. et al. (2005) Molecular biology of the cell 16, 2891-902. PMID: 15800069 3. Elbediwy, A. et al. (2012) The Journal of cell biology 198, 677-93. PMID: 22891260
Note	For research use only.

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Anti-Human CD2AP Monoclonal Antibody (1A674).pdf

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Anti-Human CD2AP Monoclonal Antibody (1A674) (HV416015)

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