| Background | Neuronal acetylcholine receptor subunit beta-2 (CHRNB2) is a ~57 kDa protein. Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNB2 forms heteropentameric neuronal acetylcholine receptors with CHRNA2, CHRNA3, CHRNA4 and CHRNA6, as well as CHRNA5 and CHRNB3 as accesory subunits. Found in two major stoichiometric forms,(CHRNA4)3:(CHRNB2)2 and (CHRNA4)2:(CHRNB2)3, the two stoichiometric forms differ in their unitary conductance, calcium permeability, ACh sensitivity and potentiation by divalent cation. 1. Bondarenko, V. et al. (2012) Biochimica et biophysica acta 1818, 1261-8. PMID: 223615912. Morales-Perez, CL. et al. (2016) Nature 538, 411-415. PMID: 276984194. Mazzaferro, S. et al. (2024) British journal of pharmacology 181, 1973-1992. PMID: 384545785. Tumkosit, P. et al. (2006) Molecular pharmacology 70, 1358-68. PMID: 168353566. Kuryatov, A. et al. (2011) Molecular pharmacology 79, 119-25. PMID: 208810057. Wang, F. et al. (1996) The Journal of biological chemistry 271, 17656-65. PMID: 86634948. George, AA. et al. (2021) The Journal of neuroscience : the official journal of the Society for Neuroscience 41, 555-575. PMID: 33239400 |
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