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Anti-CXCL12/SDF-1 Polyclonal Antibody (HW376014)

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Overview
Catalog No.HW376014
Description
Anti-CXCL12/SDF-1 Polyclonal Antibody (HW376014) is a rabbit polyclonal antibody detecting CXCL12 in ELISA, IHC, WB. Suitable for Human, Mouse, and Cat.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human CXCL12/SDF-1 (Lys22-Lys89).
Target Intercrine reduced in hepatomas, hSDF-1, Stromal cell-derived factor 1, SDF-1, Pre-B cell growth-stimulating factor, SDF1, SDF1A, C-X-C motif chemokine 12, SDF1B, CXCL12, IRH, PBSF, hIRH
Purification Purified by antigen affinity column.
Accession P48061
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background

Stromal cell-derived factor 1 (CXCL12/SDF-1) is a ~10 kDa protein. Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for CXCL12/SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase.

1. Malik, M. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 4632-7. PMID: 18802065
2. Liu, Y. et al. (2024) Cell reports 43, 114578. PMID: 39093700
3. Oberlin, E. et al. (1996) Nature 382, 833-5. PMID: 8752281
4. Balabanian, K. et al. (2005) The Journal of biological chemistry 280, 35760-6. PMID: 16107333
5. Kalatskaya, I. et al. (2009) Molecular pharmacology 75, 1240-7. PMID: 19255243
6. Fujita, M. et al. (2018) The Biochemical journal 475, 723-732. PMID: 29301984
Note For research use only.
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Datasheet
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Formula
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Anti-CXCL12/SDF-1 Polyclonal Antibody

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