Anti-GRIK2 Polyclonal Antibody (HC267014)

Name: Anti-GRIK2 Polyclonal Antibody
Brand: abinScience
SKU: HC267014
Price: 168 USD
Availability: InStock

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Datasheet
SDS

Overview

Catalog No.

HC267014

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Immunogen

E. coli - derived recombinant Human GRIK2 (Asn286-Pro561).

Target

EAA4, GluR6, Glutamate receptor 6, Excitatory amino acid receptor 4, Glutamate receptor ionotropic, kainate 2, GluK2, GLUR6, GRIK2, GluR-6

Purification

Purified by antigen affinity column.

Accession

Q13002

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Glutamate receptor ionotropic, kainate 2 (GRIK2) is a ~102 kDa protein. Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformational change leading to the opening of the cation channel, converting the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. Modulates cell surface expression of NETO2.

1. Hoo, KH. et al. (1994) Receptors & channels 2, 327-37. PMID: 7536611

2. Swanson, GT. et al. (1996) The Journal of physiology 492 ( Pt 1), 129-42. PMID: 8730589

3. Hayes, DM. et al. (2003) Biochemical and biophysical research communications 310, 8-13. PMID: 14511640

4. Guzmán, YF. et al. (2017) Neurology. Genetics 3, e129. PMID: 28180184

5. Stolz, JR. et al. (2021) American journal of human genetics 108, 1692-1709. PMID: 34375587

Note

For research use only.

Images

References

Datasheet

Anti-GRIK2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-GRIK2 Polyclonal Antibody (HC267014)

Overview

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References

Datasheet

SDS

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