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Anti-HHV-5/HCMV UL83 Polyclonal Antibody (VK643014)

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Overview
Catalog No.VK643014
Description
Anti-HHV-5/HCMV UL83 Polyclonal Antibody (VK643014) is a rabbit polyclonal antibody detecting UL83. Suitable for Human cytomegalovirus.
Species reactivityHuman cytomegalovirus (HCMV) (HHV-5) (Human herpesvirus 5)
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant HHV-5/HCMV UL83 (Thr297-Tyr510).
Target 65 kDa matrix phosphoprotein, 65 kDa phosphoprotein, Phosphoprotein UL83, Tegument protein UL83, UL83, pp65
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P06725
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

65 kDa phosphoprotein (UL83) is a ~62 kDa protein. Counteracts the host antiviral immune response when activated and phosphorylated, by preventing host IRF3 from entering the nucleus. Also inhibits the type I interferon production by inactivating the enzymatic activity of DNA sensor CGAS without affecting STING1. Participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes.

1. Abate, DA. et al. (2004) Journal of virology 78, 10995-1006. PMID: 15452220
2. Biolatti, M. et al. (2018) Journal of virology 92. PMID: 29263269
3. Cox, JB. et al. (2025) Journal of virology 99, e0048125. PMID: 40243337
4. Cristea, IM. et al. (2010) Journal of virology 84, 7803-14. PMID: 20504932
Note For research use only
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Formula
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Anti-HHV-5/HCMV UL83 Polyclonal Antibody

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