

| Catalog No. | VK643012 |
|---|---|
| Description |
Recombinant HHV-5/HCMV UL83 Protein, N-GST (VK643012). Purity: >90% as determined by SDS-PAGE..
Highlights
|
| Expression system | E. coli |
| Accession | P06725 |
| Protein length | Thr297-Tyr510 |
| Applications | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Species | Human cytomegalovirus (HCMV) (HHV-5) (Human herpesvirus 5) |
| Nature | Recombinant |
| Endotoxin level | Please contact with the lab for this information. |
| Purity | >90% as determined by SDS-PAGE. |
| Form | Lyophilized |
| Storage buffer | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Shipping | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Alternate Names | 65 kDa matrix phosphoprotein, 65 kDa phosphoprotein, Phosphoprotein UL83, Tegument protein UL83, UL83, pp65 |
| Background | 65 kDa phosphoprotein is a ~62 kDa protein. Counteracts the host antiviral immune response when activated and phosphorylated, by preventing host IRF3 from entering the nucleus. Also inhibits the type I interferon production by inactivating the enzymatic activity of DNA sensor CGAS without affecting STING1. Participates in the transactivation of viral major immediate-early genes by the recruitment of host IFI16 to the promoters pf these genes. 1. Abate, DA. et al. (2004) Journal of virology 78, 10995-1006. PMID: 15452220 2. Biolatti, M. et al. (2018) Journal of virology 92. PMID: 29263269 3. Cox, JB. et al. (2025) Journal of virology 99, e0048125. PMID: 40243337 4. Cristea, IM. et al. (2010) Journal of virology 84, 7803-14. PMID: 20504932 |
| Note | For research use only |

SDS-PAGE for Recombinant HCMV/HHV-5 pp65/UL83 Protein, N-GST
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