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Anti-HSV-2/HHV-2 glycoprotein H/gH Polyclonal Antibody (VK081024)

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Overview
Catalog No.VK081024
Description
Anti-HSV-2/HHV-2 glycoprotein H/gH Polyclonal Antibody (VK081024) is a rabbit polyclonal antibody detecting HSV-2/HHV-2 glycoprotein H/gH. Suitable for Human herpesvirus 2.
Species reactivityHuman herpesvirus 2 (HHV-2) (Human herpes simplex virus 2) (HSV-2)
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant HSV-2/HHV-2 glycoprotein H/gH (Arg49-Pro803).
Target Envelope glycoprotein H, gH
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession P89445
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Envelope glycoprotein H (gH) is a ~89 kDa protein. The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis. Interaction with host integrins ITGAV/ITGB3 triggers release of cytosolic Ca(2+) and FAK phosphorylation leading to efficient viral entry into host genital tract epithelial cells.

1. Cheshenko, N. et al. (2014) Journal of virology 88, 10026-38. PMID: 24942591
Note For research use only
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Formula
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Anti-HSV-2/HHV-2 glycoprotein H/gH Polyclonal Antibody

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