Anti-HTLV-1 Tax Polyclonal Antibody (VK044014)

Name: Anti-HTLV-1 Tax Polyclonal Antibody
Brand: abinScience
SKU: VK044014
Price: 168 USD
Availability: InStock

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Overview
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Datasheet
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Overview

Catalog No.

VK044014

Description

Anti-HTLV-1 Tax Polyclonal Antibody (VK044014) is a rabbit polyclonal antibody detecting Protein Tax-1 in ELISA, IHC, WB.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human T-cell leukemia virus 1 (HTLV-1)

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant HTLV-1 Tax (Gly26-Pro224).

Target

Protein Tax-1, Protein X-LOR, Protein PX, Trans-activating transcriptional regulatory protein of HTLV-1, Tax

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P03409

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Protein Tax-1 is a ~39 kDa protein. Transcriptional activator that governs the viral transcription from the 5'LTR via the recruitment of dimers of host phosphorylated CREB1. Together they bind cAMP response elements within the viral promoter and mediate high-level viral transcription. Increases host CREB1 O-GlcNAcylation to further increase 5'LTR transactivation. Modulates also the expression of cellular genes leading to the deregulation of T-cell proliferation, perturbing the integrity of cell cycle checkpoints, the DNA damage response and apopototic pathways. Acts as an ubiquitin E3 ligase and stimulates host IKK complex by catalyzing the assembly of free mixed-linkage polyubiquitin chains, resulting in constitutive activation of the transcription factor NF-kappa-B.

1. Kusano, S. et al. (2012) Virology 432, 343-52. PMID: 22789739

2. Tie, F. et al. (1996) Journal of virology 70, 8368-74. PMID: 8970957

3. Groussaud, D. et al. (2017) PLoS pathogens 13, e1006518. PMID: 28742148

4. Wang, C. et al. (2016) PLoS pathogens 12, e1005584. PMID: 27082114

5. Shibata, Y. et al. (2017) PLoS pathogens 13, e1006162. PMID: 28103322

Note

For research use only

Images

References

Datasheet

Anti-HTLV-1 Tax Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

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Anti-HTLV-1 Tax Polyclonal Antibody (VK044014)

Overview

Images

References

Datasheet

SDS

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