Anti-Human Abeta40/Beta-APP40 Recombinant Antibody (SAA1381) (HP529013)

Name: Anti-Human Abeta40/Beta-APP40 Recombinant Antibody (SAA1381)
Brand: abinScience
SKU: HP529013
Price: 191 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HP529013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1381

Clonality

Monoclonal

Target

Abeta40, Beta-APP40, Amyloid-beta protein 40, amyloid beta A4 precursor protein, Amyloid-beta A4 protein

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P05067

RRID

Anti-Human Abeta40/Beta-APP40 Antibody (SAA1381) (abinScience Cat# HP529013, RRID:AB_3726900)
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Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Amyloid-beta precursor protein (Abeta 40/Beta-APP 40) is a ~86 kDa protein. Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP.

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1. Baumkötter, F. et al. (2014) The Journal of neuroscience : the official journal of the Society for Neuroscience 34, 11159-72. PMID: 25122912

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2. Satpute-Krishnan, P. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 16532-7. PMID: 17062754

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3. Seamster, PE. et al. (2012) Physical biology 9, 055005. PMID: 23011729

Note

For research use only.

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