Anti-Human ACVR1C Recombinant Antibody (SAA1706) (HV040013)

Name: Anti-Human ACVR1C Recombinant Antibody (SAA1706)
Brand: abinScience
SKU: HV040013
Price: 196 USD
Availability: InStock

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1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HV040013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1706

Clonality

Monoclonal

Target

Activin receptor-like kinase 7, ALK7, ACVR1C, Activin receptor type IC, ALK-7, Activin receptor type-1C, ACTR-IC

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q8NER5

RRID

Anti-Human ACVR1C Antibody (SAA1706) (abinScience Cat# HV040013, RRID:AB_3727467)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Activin receptor type-1C (ACVR1C) is a ~54 kDa protein. Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL. Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells.

1. Xu, G. et al. (2004) The Journal of clinical endocrinology and metabolism 89, 5523-34. PMID: 15531507

2. Munir, S. et al. (2004) The Journal of biological chemistry 279, 31277-86. PMID: 15150278

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human ACVR1C Antibody (SAA1706)

References

Datasheet

Anti-Human ACVR1C Recombinant Antibody (SAA1706).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human ACVR1C Recombinant Antibody (SAA1706) (HV040013)

Overview

Images

References

Datasheet

SDS

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