Human ACVR1C Recombinant Protein (N-His) (HV040022)

Name: Human ACVR1C Recombinant Protein (N-His)
Brand: abinScience
SKU: HV040022
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HV040022
Description	Recombinant Human ACVR1C Protein, N-His (HV040022) expressed in E. coli, spanning Thr166-Ala493. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	Q8NER5
Protein length	Thr166-Ala493
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	39.42 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	ACTR-IC, ACVR1C, ALK-7, ALK7, Activin receptor type IC, Activin receptor type-1C, Activin receptor-like kinase 7, EC:2.7.11.30
Background	Activin receptor type-1C is a ~54 kDa protein. Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consists of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B, activin E and NODAL. Upon NODAL binding, activation results in increased apoptosis and reduced proliferation through suppression of AKT signaling and the activation of Smad2-dependent signaling pathway in pancreatic beta-cells, trophoblasts, epithelial or neuronal cells. 1. Xu, G. et al. (2004) The Journal of clinical endocrinology and metabolism 89, 5523-34. PMID: 15531507 2. Munir, S. et al. (2004) The Journal of biological chemistry 279, 31277-86. PMID: 15150278
Note	For research use only

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Datasheet

Human ACVR1C Recombinant Protein (N-His).pdf

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Human ACVR1C Recombinant Protein (N-His) (HV040022)

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