Anti-Human AQP4/Aquaporin-4 Polyclonal Antibody (HX181014)

Name: Anti-Human AQP4/Aquaporin-4 Polyclonal Antibody
Brand: abinScience
SKU: HX181014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HX181014

Description

Anti-Human AQP4/Aquaporin-4 Polyclonal Antibody (HX181014) is a rabbit polyclonal antibody detecting Aquaporin-4 in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human AQP4/Aquaporin-4.

Target

Aquaporin-4, AQP-4, Mercurial-insensitive water channel, MIWC, WCH4, AQP4

Purification

Purified by antigen affinity column.

Accession

P55087

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Aquaporin-4 (AQP4) is a ~34 kDa protein. Forms a water-specific channel. Plays an important role in brain water homeostasis. It is involved in glymphatic solute transport and is required for a normal rate of water exchange across the blood brain interface. Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP.

1. Ho, JD. et al. (2009) Proceedings of the National Academy of Sciences of the United States of America 106, 7437-42. PMID: 19383790

2. Yang, B. et al. (1995) The Journal of biological chemistry 270, 22907-13. PMID: 7559426

3. Misaka, T. et al. (1996) FEBS letters 381, 208-12. PMID: 8601457

4. Passchier, EMJ. et al. (2023) Brain : a journal of neurology 146, 3444-3454. PMID: 37143309

Note

For research use only.

Images

References

Datasheet

Anti-Human AQP4/Aquaporin-4 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human AQP4/Aquaporin-4 Polyclonal Antibody (HX181014)

Overview

Images

References

Datasheet

SDS

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