Anti-Human ASL Polyclonal Antibody (HY187014)

Name: Anti-Human ASL Polyclonal Antibody
Brand: abinScience
SKU: HY187014
Price: 168 USD
Availability: InStock

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SDS

Overview

Catalog No.

HY187014

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ASL (Met1-Ala464).

Target

ASAL, Arginosuccinase, Argininosuccinate lyase, ASL

Purification

Purified by antigen affinity column.

Accession

P04424

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Argininosuccinate lyase (ASL) is a ~51 kDa protein. Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues. Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway.

1. Sampaleanu, LM. et al. (2001) Biochemistry 40, 15570-80. PMID: 11747432

2. Yu, B. et al. (2001) Biochemistry 40, 15581-90. PMID: 11747433

3. Erez, A. et al. (2011) Nature medicine 17, 1619-26. PMID: 22081021

4. Walker, DC. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 9625-9. PMID: 2263616

5. Walker, DC. et al. (1997) The Journal of biological chemistry 272, 6777-83. PMID: 9045711

Note

For research use only.

Images

References

Datasheet

Anti-Human ASL Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human ASL Polyclonal Antibody (HY187014)

Overview

Images

References

Datasheet

SDS

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